Publications
2022
Original Articles
Isa, K., Tokuoka, K., Ikeda, S., Karimi, S., Kobayashi, K., Sooksawate, T., & Isa, T. (2022). Amygdala Underlies the Environment Dependency of Defense Responses Induced via Superior Colliculus. Frontiers in Neural Circuits, 15. doi:10.3389/fncir.2021.768647
Kasai, M., & Isa, T. (2022). Effects of Light Isoflurane Anesthesia on Organization of Direction and Orientation Selectivity in the Superficial Layer of the Mouse Superior Colliculus. Journal of Neuroscience, 42(4), 619-630. doi:10.1523/jneurosci.1196-21.2021
Sawamura, M., Onoe, H., Tsukada, H., Isa, K., Yamakado, H., Okuda, S., Ikuno, M., Hatanaka, Y., Murayama, S., Uemura, N., Isa, T., & Takahashi, R. (2022). Lewy Body Disease Primate Model with alpha-Synuclein Propagation from the Olfactory Bulb. Movement Disorders, 37(10), 2033-2044. doi:10.1002/mds.29161
Suzuki, M., Inoue, K., Nakagawa, H., Ishida, H., Kobayashi, K., Isa, T., Takada, M., & Nishimura, Y. (2022). A multisynaptic pathway from the ventral midbrain toward spinal motoneurons in monkeys. Journal of Physiology-London, 600(7), 1731-1752. doi:10.1113/jp282429
Takakuwa, N., Isa, K., Yamaguchi, R., Onoe, H., Takahashi, J., Yoshida, M., & Isa, T. (2022). Protocol for making an animal model of “blindsight” in macaque monkeys. STAR Protoc, 4(1), 101960. doi:10.1016/j.xpro.2022.101960
Umeda, T., Isa, T., & Nishimura, Y. (2022). Temporal dynamics of the sensorimotor convergence underlying voluntary limb movement. Proc Natl Acad Sci USA, 119(48), e2208353119. doi:10.1073/pnas.2208353119
Review articles
Isa, T. (2022). Double viral vector intersectional approaches for pathway-selective manipulation of motor functions and compensatory mechanisms. Exp Neurol, 349, 113959. doi:10.1016/j.expneurol.2021.113959
Isa, T., Tohyama, T., & Kinoshita, M. (2022). Phylogenetic view of the compensatory mechanisms in motor and sensory systems after neuronal injury. Curr Res Neurobiol, 3, 100058. doi:10.1016/j.crneur.2022.100058
2021
Original Papers
Chen, C. Y., Matrov, D., Veale, R., Onoe, H., Yoshida, M.,Miura, K., & Isa, T. (2021). Properties of visually guided saccadicbehavior and bottom-up attention in marmoset, macaque, and human. JNeurophysiol, 125(2), 437-457. https://doi.org/10.1152/jn.00312.2020
Koshimizu, Y., Isa, K., Kobayashi, K., & Isa, T. Double viral vector technology for selective manipulation of neural pathwayswith higher level of efficiency and safety. Gene Therapy. https://doi.org/10.1038/s41434-020-00212-y
Takakuwa, N., Isa, K., Onoe, H., Takahashi, J., & Isa,T. (2021). Contribution of the Pulvinar and Lateral Geniculate Nucleus tothe Control of Visually Guided Saccades in Blindsight Monkeys. Journal ofNeuroscience, 41(8), 1755-1768. https://doi.org/10.1523/jneurosci.2293-20.2020
Zubair, M., Murris, S. R., Isa, K., Onoe, H., Koshimizu,Y., Kobayashi, K., Vanduffel, W., & Isa, T. (2021). Divergent WholeBrain Projections from the Ventral Midbrain in Macaques. Cereb Cortex. https://doi.org/10.1093/cercor/bhaa399
Okada, T., Kuribayashi, H., Kaiser, L. G., Urushibata, Y.,Salibi, N., Seethamraju, R. T., Ahn, S., Thuy, D. H. D., Fujimoto, K., & Isa,T. (2021). Repeatability of proton magnetic resonance spectroscopy of thebrain at 7 T: effect of scan time on semi-localized by adiabatic selectiverefocusing and short-echo time stimulated echo acquisition mode scans and theircomparison. Quantitative Imaging in Medicine and Surgery, 11(1), 9-20. https://doi.org/10.21037/qims-20-517
2020
Original Papers
Isa, K., Sooksawate, T., Kobayashi, K., Redgrave, P.,& Isa, T. (2020). Dissecting the Tectal Output Channels forOrienting and Defense Responses. Eneuro, 7(5). https://doi.org/10.1523/eneuro.0271-20.2020
Tokuoka, K., Kasai, M., Kobayashi, K., & Isa, T.(2020). Anatomical and electrophysiological analysis of cholinergic inputs fromthe parabigeminal nucleus to the superficial superior colliculus. Journal ofNeurophysiology, 124(6), 1968-1985. https://doi.org/10.1152/jn.00148.2020
Suzuki, M., Onoe, K., Sawada, M., Takahashi, N., Higo, N.,Murata, Y., Tsukada, H., Isa, T., Onoe, H., & Nishimura, Y. (2020).The Ventral Striatum is a Key Node for Functional Recovery of Finger DexterityAfter Spinal Cord Injury in Monkeys. Cerebral Cortex, 30(5), 3259-3270. https://doi.org/10.1093/cercor/bhz307
Vancraeyenest, P., Arsenault, J. T., Li, X. L., Zhu, Q.,Kobayashi, K., Isa, K., Isa, T., & Vanduffel, W. (2020). SelectiveMesoaccumbal Pathway Inactivation Affects Motivation but NotReinforcement-Based Learning in Macaques. Neuron, 108(3), 568-+. https://doi.org/10.1016/j.neuron.2020.07.013
Cui, W. P., Aida, T., Ito, H., Kobayashi, K., Wada, Y.,Kato, S., Nakano, T., Zhu, M. N., Isa, K., Isa, T., Tanaka, K., &Aizawa, H. (2020). Dopaminergic Signaling in the Nucleus Accumbens ModulatesStress-Coping Strategies during Inescapable Stress. Journal of Neuroscience,40(38), 7241-7254. https://doi.org/10.1523/jneurosci.0444-20.2020
Kawamura, A., Katayama, Y., Nishiyama, M., Shoji, H.,Tokuoka, K., Ueta, Y., Miyata, M., Isa, T., Miyakawa, T.,Hayashi-Takagi, A., & Nakayama, K. I. (2020). Oligodendrocyte dysfunctiondue to Chd8 mutation gives rise to behavioral deficits in mice. Human MolecularGenetics, 29(8), 1274-1291. https://doi.org/10.1093/hmg/ddaa036
Susaki, E. A., Shimizu, C., Kuno, A., Tainaka, K., Li, X.,Nishi, K., Morishima, K., Ono, H., Ode, K. L., Saeki, Y., Miyamichi, K., Isa,K., Yokoyama, C., Kitaura, H., Ikemura, M., Ushiku, T., Shimizu, Y., Saito, T.,Saido, T. C., Fukayama, M., Onoe, H., Touhara, K., Isa, T., Kakita, A.,Shibayama, M., & Ueda, H. R. (2020). Versatile whole-organ/body stainingand imaging based on electrolyte-gel properties of biological tissues. NatureCommunications, 11(1). https://doi.org/10.1038/s41467-020-15906-5
2019
Original Papers
Ishida, A., Kobayashi, K., Ueda, Y., Shimizu, T., Tajiri, N., Isa, T., & Hida, H . (2019). Dynamic Interaction between Cortico-Brainstem Pathways during Training-Induced Recovery in Stroke Model Rats. Journal of Neuroscience, 39(37), 7306-7320. https://doi.org/10.1523/jneurosci.0649-19.2019
Kinoshita, M., Kato, R., Isa, K., Kobayashi, K., Onoe, H., & Isa, T. (2019). Dissecting the circuit for blindsight to reveal the critical role of pulvinar and superior colliculus. Nature Communications, 10. https://doi.org/10.1038/s41467-018-08058-0
Sugiyama, Y., Oishi, T., Yamashita, A., Murata, Y., Yamamoto, T., Takashima, I., Isa, T., & Higo, N. (2019). Neuronal and microglial localization of secreted phosphoprotein 1 (osteopontin) in intact and damaged motor cortex of macaques. BrainResearch, 1714, 52-64. https://doi.org/10.1016/j.brainres.2019.02.021
Suzuki, M., Onoe, K., Sawada, M., Takahashi, N., Higo, N., Murata, Y., Tsukada, H., Isa, T., Onoe, H., & Nishimura, Y. (2019). The Ventral Striatum is a Key Node for Functional Recovery of Finger Dexterity After Spinal Cord Injury in Monkeys. Cereb Cortex. https://doi.org/10.1093/cercor/bhz307
Umeda, T., Isa, T., & Nishimura, Y. (2019). The somatosensory cortex receives information about motor output. Science Advances, 5(7). https://doi.org/10.1126/sciadv.aaw5388
Chao, Z. C., Sawada, M., Isa, T., & Nishimura, Y. (2019). Dynamic Reorganization of Motor Networks During Recovery from Partial Spinal Cord Injury in Monkeys. CerebralCortex, 29(7), 3059-3073. https://doi.org/10.1093/cercor/bhy172
Review Articles
Isa, T . (2019). Dexterous Hand Movements and Their Recovery After Central Nervous System Injury. Annu Rev Neurosci, 42, 315-335. https://doi.org/10.1146/annurev-neuro-070918-050436
Isa, T., Mitsuhashi, M., & Yamaguchi, R. (2019). Alternative routes for recovery of hand functions after corticospinal tract injury in primates and rodents. CurrentOpinion in Neurology, 32(6), 836-843. https://doi.org/10.1097/wco.0000000000000749