Publications
2022
Original Articles
Gyobu-Motani, S., Yabuta, Y., Mizuta, K., Katou, Y., Okamoto, I., Kawasaki, M., Kitamura, A., Tsukiyama, T., Iwatani, C., Tsuchiya, H., Tsujimura, T., Yamamoto, T., Nakamura, T., & Saitou, M. (2023). Induction of fetal meiotic oocytes from embryonic stem cells in cynomolgus monkeys. Embo Journal. doi:10.15252/embj.2022112962
Fujita, Y., Hirosawa, M., Hayashi, K., Hatani, T., Yoshida, Y., Yamamoto, T., & Saito, H. (2022). A versatile and robust cell purification system with an RNA-only circuit composed of microRNA-responsive ON and OFF switches. Science Advances, 8(1). doi:10.1126/sciadv.abj1793
Hashimoto, R., Takahashi, J., Shirakura, K., Funatsu, R., Kosugi, K., Deguchi, S., Yamamoto, M., Tsunoda, Y., Morita, M., Muraoka, K., Tanaka, M., Kanbara, T., Tanaka, S., Tamiya, S., Tokunoh, N., Kawai, A., Ikawa, M., Ono, C., Tachibana, K., Kondoh, M., Obana, M., Matsuura, Y., Ohsumi, A., Noda, T., Yamamoto, T., Yoshioka, Y., Torisawa, Y. S., Date, H., Fujio, Y., Nagao, M., Takayama, K., & Okada, Y. (2022). SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression. Science Advances, 8(38). doi:10.1126/sciadv.abo6783
Hirano, M., So, Y., Tsunekawa, S., Kabata, M., Ohta, S., Sagara, H., Sankoda, N., Taguchi, J., Yamada, Y., Ukai, T., Kato, M., Nakamura, J., Ozawa, M., & Yamamoto, T. (2022). MYCL-mediated reprogramming expands pancreatic insulin-producing cells. Nature Metabolism, 4(2), 254-+. doi:10.1038/s42255-022-00530-y
Ichijo, R., Maki, K., Kabata, M., Murata, T., Nagasaka, A., Ishihara, S., Haga, H., Honda, T., Adachi, T., Yamamoto, T., & Toyoshima, F. (2022). Vasculature atrophy causes a stiffened microenvironment that augments epidermal stem cell differentiation in aged skin. Nature Aging, 2(7), 592-+. doi:10.1038/s43587-022-00244-6
Imoto, Y., Nakamura, T., Escolar, E. G., Yoshiwaki, M., Kojima, Y., Yabuta, Y., Katou, Y., Yamamoto, T., Hiraoka, Y., & Saitou, M. (2022). Resolution of the curse of dimensionality in single-cell RNA sequencing data analysis. Life Science Alliance, 5(12). doi:10.26508/lsa.202201591
Ito, K., Nagata, K., Ohta, S., Matsuda, Y., Ukai, T., Yasuda, I., Ota, A., Kobayashi, R., Kabata, M., Sankoda, N., Maeda, T., Woltjen, K., Yang, L. Y., Maruyama, R., Katayama, R., Yamamoto, T., & Yamada, Y. (2022). The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets. Cell Reports, 39(4). doi:10.1016/j.celrep.2022.110721
Iwasaki, M., Kawahara, Y., Okubo, C., Yamakawa, T., Nakamura, M., Tabata, T., Nishi, Y., Narita, M., Ohta, A., Saito, H., Yamamoto, T., Nakagawa, M., Yamanaka, S., & Takahashi, K. (2022). Multi-omics approach reveals posttranscriptionally regulated genes are essential for human pluripotent stem cells. Iscience, 25(5). doi:10.1016/j.isci.2022.104289
Kozuki, S., Sakurai, S., Suzuki, A., Yamamoto, T., & Toyoshima, F. (2022). Delineation of biliary epithelial cell dynamics in maternal liver during pregnancy. Genes to Cells, 27(3), 192-201. doi:10.1111/gtc.12918
Nagano, M., Hu, B., Yokobayashi, S., Yamamura, A., Umemura, F., Coradin, M., Ohta, H., Yabuta, Y., Ishikura, Y., Okamoto, I., Ikeda, H., Kawahira, N., Nosaka, Y., Shimizu, S., Kojima, Y., Mizuta, K., Kasahara, T., Imoto, Y., Meehan, K., Stocsits, R., Wutz, G., Hiraoka, Y., Murakawa, Y., Yamamoto, T., Tachibana, K., Peters, J. M., Mirny, L. A., Garcia, B. A., Majewski, J., & Saitou, M. (2022). Nucleome programming is required for the foundation of totipotency in mammalian germline development. Embo Journal, 41(13). doi:10.15252/embj.2022110600
Nalbandian, M., Zhao, M. M., Kato, H., Jonouchi, T., Nakajima-Koyama, M., Yamamoto, T., & Sakurai, H. (2022). Single-cell RNA-seq reveals heterogeneity in hiPSC-derived muscle progenitors and E2F family as a key regulator of proliferation. Life Science Alliance, 5(8). doi:10.26508/lsa.202101312
Oikawa, M., Kobayashi, H., Sanbo, M., Mizuno, N., Iwatsuki, K., Takashima, T., Yamauchi, K., Yoshida, F., Yamamoto, T., Shinohara, T., Nakauchi, H., Kurimoto, K., Hirabayashi, M., & Kobayashi, T. (2022). Functional primordial germ cell-like cells from pluripotent stem cells in rats. Science, 376(6589), 176-+. doi:10.1126/science.abl4412
Oka, K., Fujioka, S., Kawamura, Y., Komohara, Y., Chujo, T., Sekiguchi, K., Yamamura, Y., Oiwa, Y., Omamiuda-Ishikawa, N., Komaki, S., Sutoh, Y., Sakurai, S., Tomizawa, K., Bono, H., Shimizu, A., Araki, K., Yamamoto, T., Yamada, Y., Oshiumi, H., & Miura, K. (2022). Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats. Commun Biol, 5(1), 287. doi:10.1038/s42003-022-03241-y
Sano, E., Suzuki, T., Hashimoto, R., Itoh, Y., Sakamoto, A., Sakai, Y., Saito, A., Okuzaki, D., Motooka, D., Muramoto, Y., Noda, T., Takasaki, T., Sakuragi, J. I., Minami, S., Kobayashi, T., Yamamoto, T., Matsumura, Y., Nagao, M., Okamoto, T., & Takayama, K. (2022). Cell response analysis in SARS-CoV-2 infected bronchial organoids. Communications Biology, 5(1). doi:10.1038/s42003-022-03499-2
Sato, Y., Oguchi, A., Fukushima, Y., Masuda, K., Toriu, N., Taniguchi, K., Yoshikawa, T., Cui, X. T., Kondo, M., Hosoi, T., Komidori, S., Shimizu, Y., Fujita, H., Jiang, L., Kong, Y. Y., Yamanashi, T., Seita, J., Yamamoto, T., Toyokuni, S., Hamazaki, Y., Hattori, M., Yoshikai, Y., Boor, P., Floege, J., Kawamoto, H., Murakawa, Y., Minato, N., & Yanagita, M. (2022). CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury. Journal of Clinical Investigation, 132(2). doi:10.1172/jci146071
Sawada, A., Yamamoto, T., & Sato, T. (2022). Tceal5 and Tceal7 Function in C2C12 Myogenic Differentiation via Exosomes in Fetal Bovine Serum. International Journal of Molecular Sciences, 23(4). doi:10.3390/ijms23042036
Yamanaka, Y., Hamidi, S., Yoshioka-Kobayashi, K., Munira, S., Sunadome, K., Zhang, Y., Kurokawa, Y., Ericsson, R., Mieda, A., Thompson, J. L., Kerwin, J., Lisgo, S., Yamamoto, T., Moris, N., Martinez-Arias, A., Tsujimura, T., & Alev, C. Reconstituting human somitogenesis in vitro. Nature. doi:10.1038/s41586-022-05649-2
Review articles
Matsumoto, R., Suga, H., Arima, H., & Yamamoto, T. (2022). Disease Modeling of Pituitary Adenoma Using Human Pluripotent Stem Cells. Cancers, 14(15). doi:10.3390/cancers14153660
Matsumoto, R., Yamamoto, T., & Takahashi, Y. (2021). Complex Organ Construction from Human Pluripotent Stem Cells for Biological Research and Disease Modeling with New Emerging Techniques. Int J Mol Sci, 22(19). doi:10.3390/ijms221910184
2021
Original Papers
Kojima, Y., Yamashiro, C., Murase, Y., Yabuta, Y., Okamoto, I., Iwatani, C., Tsuchiya, H., Nakaya, M., Tsukiyama, T., Nakamura, T., Yamamoto, T., & Saitou, M. (2021). GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program. Life Sci Alliance, 4(5). https://doi.org/10.26508/lsa.202000974
Io, S., Kabata, M., Iemura, Y., Semi, K., Morone, N., Minagawa, A., Wang, B., Okamoto, I., Nakamura, T., Kojima, Y., Iwatani, C., Tsuchiya, H., Kaswandy, B., Kondoh, E., Kaneko, S., Woltjen, K., Saitou, M.,Yamamoto, T., Mandai, M., & Takashima, Y. (2021). Capturing human trophoblast development with naive pluripotent stem cells in vitro. Cell Stem Cell. https://doi.org/10.1016/j.stem.2021.03.013
Ichijo, R., Kabata, M., Kidoya, H., Muramatsu, F., Ishibashi, R., Abe, K., Tsutsui, K., Kubo, H., Iizuka, Y., Kitano, S., Miyachi,H., Kubota, Y., Fujiwara, H., Sada, A., Yamamoto, T., & Toyoshima,F. (2021). Vasculature-driven stem cell population coordinates tissue scaling in dynamic organs. Sci Adv, 7(7). https://doi.org/10.1126/sciadv.abd2575
Katagiri, N., Hitomi, H., Mae, S. I., Kotaka, M., Lei, L., Yamamoto, T., Nishiyama, A., & Osafune, K. (2021). Retinoic acid regulates erythropoietin production cooperatively with hypoxia-inducible factors in human iPSC-derived erythropoietin-producing cells. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-83431-6
Morimoto, H., Yamamoto, T., Miyazaki, T., Ogonuki,N., Ogura, A., Tanaka, T., Kanatsu-Shinohara, M., Yabe-Nishimura, C., Zhang, H.L., Pommier, Y., Trumpp, A., & Shinohara, T. (2021). An interplay of NOX1-derived ROS and oxygen determines the spermatogonial stem cell self-renewal efficiency under hypoxia. Genes & Development, 35(3-4). https://doi.org/10.1101/gad.339903.120
Sankoda, N., Tanabe, W., Tanaka, A., Shibata, H., Woltjen, K., Chiba, T., Haga, H., Sakai, Y., Mandai, M., Yamamoto, T., Yamada,Y., Uemoto, S., & Kawaguchi, Y. (2021). Epithelial expression of Gata4 and Sox2 regulates specification of the squamous-columnar junction via MAPK/ERK signaling in mice. Nat Commun, 12(1), 560. https://doi.org/10.1038/s41467-021-20906-0
Sano, E., Deguchi, S., Sakamoto, A., Mimura, N., Hirabayashi, A., Muramoto, Y., Noda, T., Yamamoto, T., & Takayama,K. (2021). Modeling SARS-CoV-2 infection and its individual differences with ACE2-expressing human iPS cells. iScience, 102428. https://doi.org/10.1016/j.isci.2021.102428
Yuzuriha, A, Nakamura, S, Sugimoto, N, Kihara, S,Nakagawa, M, Yamamoto, T, Sekiguchi, K, & Eto, K. (2021).Extracellular laminin regulates hematopoietic potential of pluripotent stemcells through integrin β1-ILK-β-catenin-JUN axis. Stem Cell Research, 53,102287.
2020
Original Papers
Matsuda, M., Yamanaka, Y., Uemura, M., Osawa, M., Saito, M. K., Nagahashi, A., Nishio, M., Guo, L., Ikegawa, S., Sakurai, S., Kihara,S., Maurissen, T. L., Nakamura, M., Matsumoto, T., Yoshitomi, H., Ikeya, M.,Kawakami, N., Yamamoto, T., Woltjen, K., Ebisuya, M., Toguchida, J.,& Alev, C. (2020). Recapitulating the human segmentation clock with pluripotent stem cells. Nature, 580(7801), 124-+. https://doi.org/10.1038/s41586-020-2144-9
Murase, Y., Yabuta, Y., Ohta, H., Yamashiro, C., Nakamura,T., Yamamoto, T., & Saitou, M. (2020). Long-term expansion with germline potential of human primordial germ cell-like cells in vitro. Embo Journal, 39(21). https://doi.org/10.15252/embj.2020104929
Nagaoka, S. I., Nakaki, F., Miyauchi, H., Nosaka, Y., Ohta, H., Yabuta, Y., Kurimoto, K., Hayashi, K., Nakamura, T., Yamamoto, T.,& Saitou, M. (2020). ZGLP1 is a determinant for the oogenic fate inmice. Science, 367(6482), 1089-+. https://doi.org/10.1126/science.aaw4115
Ohta, H, Yabuta, Y, Kurimoto, K, Nakamura, T, Murase, Y, Yamamoto,T, & Saitou, M. (2020). Cyclosporin A and FGF signaling support the proliferation/survival of mouse primordial germ cell-like cells in vitro. Biology of Reproduction. https://doi.org/10.1093/biolre/ioaa195
Sakai, Y., Nakamura, T., Okamoto, I., Gyobu-Motani, S.,Ohta, H., Yabuta, Y., Tsukiyama, T., Iwatani, C., Tsuchiya, H., Ema,M., Morizane, A., Takahashi, J., Yamamoto, T., & Saitou, M.(2020). Induction of the germ cell fate from pluripotent stem cells in cynomolgus monkeys. Biology of Reproduction, 102(3), 620-638. https://doi.org/10.1093/biolre/ioz205
Senoo, M., Hozoji, H., Ishikawa-Yamauchi, Y., Takijiri, T., Ohta, S., Ukai, T., Kabata, M., Yamamoto, T., Yamada, Y., Ikawa, M.,& Ozawa, M. (2020). RNA-binding protein Ptbp1 regulates alternative splicing and transcriptome in spermatogonia and maintains spermatogenesis in concert with Nanos3. Journal of Reproduction and Development, 66(5),459-467. https://doi.org/10.1262/jrd.2020-060
Yagi, M., Kabata, M., Tanaka, A., Ukai, T., Ohta, S., Nakabayashi, K., Shimizu, M., Hata, K., Meissner, A., Yamamoto, T.,& Yamada, Y. (2020). Identification of distinct loci for de novo DNAm ethylation by DNMT3A and DNMT3B during mammalian development. Nature Communications, 11(1). https://doi.org/10.1038/s41467-020-16989-w
2019
Original Papers
Arai, H. N., Sato, F., Yamamoto, T., Woltjen, K., Kiyonari, H., Yoshimoto, Y., Shukunami, C., Akiyama, H., Kist, R., & Sehara-Fujisawa, A. (2019). Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac NeuralCrest Cell Fate. Cell Reports, 29(3), 603-+. https://doi.org/10.1016/j.celrep.2019.09.019
Komura, S., Ito, K., Ohta, S., Ukai, T., Kabata, M., Itakura, F., Semi, K., Matsuda, Y., Hashimoto, K., Shibata, H., Sone, M., Jo, N., Sekiguchi, K., Ohno, T., Akiyama, H., Shimizu, K., Woltjen, K., Ozawa, M., Toguchida, J., Yamamoto, T., &Yamada, Y. (2019). Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas. Nature Communications, 10. https://doi.org/10.1038/s41467-019-11745-1
Morimoto, H., Kanastu-Shinohara, M., Ogonuki, N., Kamimura, S., Ogura, A., Yabe-Nishimura, C., Mori, Y., Morimoto, T., Watanabe, S., Otsu, K., Yamamoto, T., & Shinohara, T. (2019). ROS amplification drives mouse spermatogonialstem cell self-renewal. Life Science Alliance, 2(2). https://doi.org/10.26508/lsa.201900374
Sakakura, M., Ohta, S., Yagi, M., Tanaka, A., Norihide, J., Woltjen, K., Yamamoto, T., & Yamada, Y. (2019). Smarcb1 maintains the cellular identity and the chromatin landscapes of mouse embryonic stem cells. Biochemical andBiophysical Research Communications, 519(4), 705-713. https://doi.org/10.1016/j.bbrc.2019.09.054
Terada, Y., Jo, N., Arakawa, Y., Sakakura, M., Yamada, Y., Ukai, T., Kabata, M., Mitsunaga, K., Mineharu, Y., Ohta, S., Nakagawa, M., Miyamoto, S., Yamamoto, T. &Yamada Y. (2019). Human Pluripotent Stem Cell-Derived Tumor Model Uncovers the Embryonic Stem Cell Signature as a Key Driver in Atypical Teratoid/Rhabdoid Tumor. Cell Reports, 26(10), 2608-+. https://doi.org/10.1016/j.celrep.2019.02.009
Yagi, M., Kabata, M., Ukai, T., Ohta, S., Tanaka, A., Shimada, Y., Sugimoto, M., Araki, K., Okita, K., Woltjen, K., Hochedlinger, K., Yamamoto, T., & Yamada, Y . (2019). De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency. Stem Cell Reports, 12(5), 1113-1128. https://doi.org/10.1016/j.stemcr.2019.04.008
Hirata, K., Kodama, S., Nakano, Y., Minaki-Nakagawa, Y., Aoyama, Y., Sakikubo, M., Goto, T., Yoshida, M., Masui, T., Yamamoto, T., Uemoto, S., & Kawaguchi, Y . (2019). Exocrine tissue-driven TFF2 prevents apoptotic cell death of endocrine lineage during pancreas organogenesis. Scientific Reports, 9. https://doi.org/10.1038/s41598-018-38062-9
Kagawa, H., Shimamoto, R., Kim, S. I., Oceguera-Yanez, F., Yamamoto, T., Schroeder, T., & Woltjen, K. (2019). OVOL1 Influences the Determination and Expansion of iPSC Reprogramming Intermediates. Stem Cell Reports, 12(2), 319-332. https://doi.org/10.1016/j.stemcr.2018.12.008
Kanatsu-Shinohara, M., Yamamoto, T., Toh, H., Kazuki, Y., Kazuki, K., Imoto, J., Ikeo, K., Oshima, M., Shirahige, K., Iwama, A., Nabeshima, Y., Sasaki, H., & Shinohara, T . (2019). Aging of spermatogonial stem cells by Jnk-mediated glycolysis activation. Proceedings of the National Academy of Sciences of the UnitedStates of America, 116(33), 16404-16409. https://doi.org/10.1073/pnas.1904980116
Matsui, S., Ochiai, M., Yasuda, K., Mae, S., Kotaka, M., Toyoda, T., Yamamoto, T., & Osafune, K. (2019). Differentiation and isolation of iPSC-derived remodeling ductal plate-like cells by use of an AQP1-GFP reporter human iPSC line. Stem Cell Research, 35. https://doi.org/10.1016/j.scr.2019.101400
Sato, T., Higashioka, K., Sakurai, H., Yamamoto, T., Goshima, N., Ueno, M., &Sotozono, C. (2019). Core Transcription Factors Promote Induction ofPAX3-Positive Skeletal Muscle Stem Cells. Stem Cell Reports, 13(2), 352-365. https://doi.org/10.1016/j.stemcr.2019.06.006