Kyoto University Institute for the
Advanced Study of Human Biology






Isa, K., Tokuoka, K., Ikeda, S., Karimi, S., Kobayashi, K., Sooksawate, T., & Isa, T. (2022). Amygdala Underlies the Environment Dependency of Defense Responses Induced via Superior Colliculus. Frontiers in Neural Circuits, 15. doi:10.3389/fncir.2021.768647

Kasai, M., & Isa, T. (2022). Effects of Light Isoflurane Anesthesia on Organization of Direction and Orientation Selectivity in the Superficial Layer of the Mouse Superior Colliculus. Journal of Neuroscience, 42(4), 619-630. doi:10.1523/jneurosci.1196-21.2021

Sawamura, M., Onoe, H., Tsukada, H., Isa, K., Yamakado, H., Okuda, S., Ikuno, M., Hatanaka, Y., Murayama, S., Uemura, N., Isa, T., & Takahashi, R. (2022). Lewy Body Disease Primate Model with alpha-Synuclein Propagation from the Olfactory Bulb. Movement Disorders, 37(10), 2033-2044. doi:10.1002/mds.29161

Suzuki, M., Inoue, K., Nakagawa, H., Ishida, H., Kobayashi, K., Isa, T., Takada, M., & Nishimura, Y. (2022). A multisynaptic pathway from the ventral midbrain toward spinal motoneurons in monkeys. Journal of Physiology-London, 600(7), 1731-1752. doi:10.1113/jp282429

Takakuwa, N., Isa, K., Yamaguchi, R., Onoe, H., Takahashi, J., Yoshida, M., & Isa, T. (2022). Protocol for making an animal model of “blindsight” in macaque monkeys. STAR Protoc, 4(1), 101960. doi:10.1016/j.xpro.2022.101960

Umeda, T., Isa, T., & Nishimura, Y. (2022). Temporal dynamics of the sensorimotor convergence underlying voluntary limb movement. Proc Natl Acad Sci USA, 119(48), e2208353119. doi:10.1073/pnas.2208353119


Isa, T. (2022). Double viral vector intersectional approaches for pathway-selective manipulation of motor functions and compensatory mechanisms. Exp Neurol, 349, 113959. doi:10.1016/j.expneurol.2021.113959

Isa, T., Tohyama, T., & Kinoshita, M. (2022). Phylogenetic view of the compensatory mechanisms in motor and sensory systems after neuronal injury. Curr Res Neurobiol, 3, 100058. doi:10.1016/j.crneur.2022.100058



Chen, C. Y., Matrov, D., Veale, R., Onoe, H., Yoshida, M.,Miura, K., & Isa, T. (2021). Properties of visually guided saccadicbehavior and bottom-up attention in marmoset, macaque, and human. JNeurophysiol, 125(2), 437-457.

Koshimizu, Y., Isa, K., Kobayashi, K., & Isa, T. Double viral vector technology for selective manipulation of neural pathwayswith higher level of efficiency and safety. Gene Therapy.

Takakuwa, N., Isa, K., Onoe, H., Takahashi, J., & Isa,T. (2021). Contribution of the Pulvinar and Lateral Geniculate Nucleus tothe Control of Visually Guided Saccades in Blindsight Monkeys. Journal ofNeuroscience, 41(8), 1755-1768.

Zubair, M., Murris, S. R., Isa, K., Onoe, H., Koshimizu,Y., Kobayashi, K., Vanduffel, W., & Isa, T. (2021). Divergent WholeBrain Projections from the Ventral Midbrain in Macaques. Cereb Cortex.

Okada, T., Kuribayashi, H., Kaiser, L. G., Urushibata, Y.,Salibi, N., Seethamraju, R. T., Ahn, S., Thuy, D. H. D., Fujimoto, K., & Isa,T. (2021). Repeatability of proton magnetic resonance spectroscopy of thebrain at 7 T: effect of scan time on semi-localized by adiabatic selectiverefocusing and short-echo time stimulated echo acquisition mode scans and theircomparison. Quantitative Imaging in Medicine and Surgery, 11(1), 9-20.



Isa, K., Sooksawate, T., Kobayashi, K., Redgrave, P. ,& Isa, T. (2020). Dissecting the Tectal Output Channels forOrienting and Defense Responses. Eneuro, 7(5).

Tokuoka, K., Kasai, M., Kobayashi, K., & Isa, T.(2020). Anatomical and electrophysiological analysis of cholinergic inputs fromthe parabigeminal nucleus to the superficial superior colliculus. Journal ofNeurophysiology, 124(6), 1968-1985.

Suzuki, M., Onoe, K., Sawada, M., Takahashi, N., Higo, N.,Murata, Y., Tsukada, H., Isa, T., Onoe, H., & Nishimura, Y. (2020).The Ventral Striatum is a Key Node for Functional Recovery of Finger DexterityAfter Spinal Cord Injury in Monkeys. Cerebral Cortex, 30(5), 3259-3270.

Vancraeyenest, P., Arsenault, J. T., Li, X. L., Zhu, Q.,Kobayashi, K., Isa, K., Isa, T., & Vanduffel, W. (2020). SelectiveMesoaccumbal Pathway Inactivation Affects Motivation but NotReinforcement-Based Learning in Macaques. Neuron, 108(3), 568-+.

Cui, W. P., Aida, T., Ito, H., Kobayashi, K., Wada, Y.,Kato, S., Nakano, T., Zhu, M. N., Isa, K., Isa, T., Tanaka, K., &Aizawa, H. (2020). Dopaminergic Signaling in the Nucleus Accumbens ModulatesStress-Coping Strategies during Inescapable Stress. Journal of Neuroscience,40(38), 7241-7254.

Kawamura, A., Katayama, Y., Nishiyama, M., Shoji, H.,Tokuoka, K., Ueta, Y., Miyata, M., Isa, T., Miyakawa, T.,Hayashi-Takagi, A., & Nakayama, K. I. (2020). Oligodendrocyte dysfunctiondue to Chd8 mutation gives rise to behavioral deficits in mice. Human MolecularGenetics, 29(8), 1274-1291.

Susaki, E. A., Shimizu, C., Kuno, A., Tainaka, K., Li, X.,Nishi, K., Morishima, K., Ono, H., Ode, K. L., Saeki, Y., Miyamichi, K., Isa,K., Yokoyama, C., Kitaura, H., Ikemura, M., Ushiku, T., Shimizu, Y., Saito, T.,Saido, T. C., Fukayama, M., Onoe, H., Touhara, K., Isa, T., Kakita, A.,Shibayama, M., & Ueda, H. R. (2020). Versatile whole-organ/body stainingand imaging based on electrolyte-gel properties of biological tissues. NatureCommunications, 11(1).



Ishida, A., Kobayashi, K., Ueda, Y., Shimizu, T., Tajiri, N., Isa, T., & Hida, H . (2019). Dynamic Interaction between Cortico-Brainstem Pathways during Training-Induced Recovery in Stroke Model Rats. Journal of Neuroscience, 39(37), 7306-7320.

Kinoshita, M., Kato, R., Isa, K., Kobayashi, K., Onoe, H., & Isa, T. (2019). Dissecting the circuit for blindsight to reveal the critical role of pulvinar and superior colliculus. Nature Communications, 10.

Sugiyama, Y., Oishi, T., Yamashita, A., Murata, Y., Yamamoto, T., Takashima, I., Isa, T., & Higo, N. (2019). Neuronal and microglial localization of secreted phosphoprotein 1 (osteopontin) in intact and damaged motor cortex of macaques. BrainResearch, 1714, 52-64.

Suzuki, M., Onoe, K., Sawada, M., Takahashi, N., Higo, N., Murata, Y., Tsukada, H., Isa, T., Onoe, H., & Nishimura, Y. (2019). The Ventral Striatum is a Key Node for Functional Recovery of Finger Dexterity After Spinal Cord Injury in Monkeys. Cereb Cortex.

Umeda, T., Isa, T., & Nishimura, Y. (2019). The somatosensory cortex receives information about motor output. Science Advances, 5(7).

Chao, Z. C., Sawada, M., Isa, T., & Nishimura, Y. (2019). Dynamic Reorganization of Motor Networks During Recovery from Partial Spinal Cord Injury in Monkeys. CerebralCortex, 29(7), 3059-3073.


Isa, T . (2019). Dexterous Hand Movements and Their Recovery After Central Nervous System Injury. Annu Rev Neurosci, 42, 315-335.

Isa, T., Mitsuhashi, M., & Yamaguchi, R. (2019). Alternative routes for recovery of hand functions after corticospinal tract injury in primates and rodents. CurrentOpinion in Neurology, 32(6), 836-843.