Yoshitaka Honda

Research Overview

1. To elucidate the molecular mechanisms underlying tissue-specific regulation of human adaptive immune response

The immune system detects invading pathogens and launch immune response to eliminate them. Recent evidence shows that regulatory mechanisms of immune response are drastically different and significantly impacted according to the anatomical location. These mechanisms enable to induce distinct types of adaptive immune responses optimal for the specific tissues and organs. However, the precise molecular mechanisms underlying tissue-specific regulation of the adaptive immune responses in various human organs and tissues remain largely unknown.

To address this problem, we will analyze the phenotypes and functions of the immune cells in various human tissues and organs.

2. To understand the molecular mechanism of early-onset autoimmunity in the inborn errors of immunity

Inborn errors of immunity (IEI) cause early-onset autoimmunity, malignancy and severe allergy as well as predisposition to various pathogens. However, the mechanistic link between autoimmunity and IEI remains largely unknown. To investigate molecular mechanisms which causes predisposition to autoimmunity in IEI, we will perform precise immune cell profiling and analyze the immune cells obtained from the patients or differentiated from disease-model iPS cells.

Biography

Publications

Journal of Clinical Immunology. 2021. “Rapid flow cytometry-based assay for the functional classification of MEFV variants”, Honda Y*, Y Maeda*, Kazushi Izawa, Takeshi Shiba, Takayuki Tanaka, Haruna Nakaseko, Keisuke Nishimura, Hiroki Mukoyama, Masahiko Isa-Nishitani, Takayuki Miyamoto, Hiroshi Nihira, Hirofumi Shibata, Eitaro Hiejima, Osamu Ohara, Junko Takita, Takahiro Yasumi, Ryuta Nishikomori. (* equal contribution)

Arthritis Rheumatol. 2021. “Augmentation of STING-induced type I interferon production in COPA syndrome”, Kato T, Yamamoto M, Honda Y, Orimo T, Sasaki I, Murakami K, Hemmi H, Fukuda-Ohta Y, Isono K, Takayama S, Nakamura H, Otsuki Y, Miyamoto T, Takita J, Yasumi T, Nishikomori R, Matsubayashi T, Izawa K, Kaisho T.

Rheumatology (Oxford). 2020. “Successful　treatment of spondyloenchondrodysplasia with baricitinib”. Shimizu M, Inoue N, Mizuta M, Irabu H, Okajima M, Honda Y, Nihira H, Izawa K, Yachie A, Wada T.

Ann Rheum Dis. 2020. “Clinical characteristics and treatment of 50 cases of Blau syndrome in Japan confirmed by genetic analysis of the NOD2 mutation”. Matsuda T, Kambe N, Ueki Y, Kanazawa N, Izawa K, Honda Y, Kawakami A, Takei S, Tonomura K, Inoue M, Kobayashi H, Okafuji I, Sakurai Y, Kato N, Maruyama Y, Inoue Y, Otsubo Y, Makino T, Okada S, Kobayashi I, Yashiro M, Ito S, Fujii H, Kondo Y, Okamoto N, Ito S, Iwata N, Kaneko U, Doi M, Hosokawa J, Ohara O, Saito MK, Nishikomori R; PIDJ members in the JSIAD; PIDJ (Primary Immunodeficiency and Autoinflammatory Diseases Database Project) members in the JSIAD (Japanese Society for Immunodeficiency and Autoinflammatory Diseases).

Mod Rheumatol. 2020. “Haploinsufficiency of A20 with a novel mutation of deletion of exons 2-3 of TNFAIP3.” Shimizu M, Matsubayashi T, Ohnishi H, Nakama M, Izawa K, Honda Y, Nishikomori R.

J Clin Invest. 2019, 1; 129(2): 583-597. Rescue of recurrent deep intronic mutation underlying cell type-dependent quantitative NEMO deficiency. Boisson B*, Honda Y*, Ajiro M, Bustamante J, Bendavid M, Gennery AR, Kawasaki Y, Ichishima J, Osawa M, Nihira H, Shiba T, Tanaka T, Chrabieh M, Bigio B, Hur H, Itan Y, Liang Y, Okada S, Izawa K, Nishikomori R, Ohara O, Heike T, Abel L, Puel A, Saito MK, Casanova JL, Hagiwara M, Yasumi T. (* equal contribution)

Front Endorinol. 2017. 8; 157. A Case with Spondyloenchondrodysplasia Treated with Growth Hormone. Utsumi T, Okada S, Izawa K, Honda Y, Nishimura G, Nishikomori R, Okano R, Kobayashi M.

J Clin Virol. 2016. 85: 44-47. Vaccine-strain herpes zoster found in the trigeminal nerve area in a healthy child: A case report. Iwasaki S, Motokura K, Honda Y, Mikami M, Hata D, Hata A.

Rheumatol Int. 2016. 36(10): 1477-8.　Febrile attacks triggered by milk allergy in an infant with mevalonate kinase deficiency. Nakashimai H, Miyake F, Ohki S, Hattori S, Matsubayashi T, Izawa K, Nishikomori R, Heike T, Honda Y, Shigematsu Y.

Arthritis and Rheumatol. 2016. “Brief Report: Late-Onset Cryopyrin-Associated Periodic Syndrome Due to Myeloid-Restricted Somatic NLRP3 Mosaicism.” Mensa-Vilaro A, Teresa Bosque M, Magri G, Honda Y, Martínez-Banaclocha H, Casorran-Berges M, Sintes J, González-Roca E, Ruiz-Ortiz E, Heike T, Martínez-Garcia JJ, Baroja-Mazo A, Cerutti A, Nishikomori R, Yagüe J, Pelegrín P, Delgado-Beltran C, Aróstegui JI.

Awards