[Event Report] The 2nd ASHBi SignAC Workshop: Integrating Single-cell Analysis and Mathematics

December 10, 2021

[Event Report] The 2nd ASHBi SignAC Workshop: Integrating Single-cell Analysis and Mathematics

ASHBi held the 2nd ASHBi SignAC Workshop: Integrating Single-cell Analysis and Mathematics on 10 December 2021, online! A total of about 250 researchers and students from Japan and abroad participated in the workshop.

2nd ASHBi SignAC Workshop Photo 1

The 2nd ASHBi SignAC workshop was held to overview recent trends in single-cell biology. The workshop particularly featured how mathematics has been applied to the analysis of the high-dimensional data obtained from single-cell techniques. The keynote speaker in the morning session was Dr. Schiebinger. He talked about his pioneering work of applying optimal transportation theory to trajectory inference from time-series single-cell transcriptome data.

In Session 1, Dr. Nishiyama, Dr. Takei, and Dr. Ochiai talked about cutting-edge technologies to unveil genome regulation at single-cell and single-molecule resolution. In Session 2, Dr. Hon first discussed single-cell multi-omics analysis. Then, Dr. Yamanishi, and Dr. Imoto introduced their novel mathematical methods to extract valuable information from such high-dimensional data. In Session 3, Dr. Yamamoto and Dr. Suzuki presented how the recent single-cell technologies can be applied to tackle problems in hematopoiesis and cancer biology, respectively. Finally, at the keynote lecture in the evening, Dr. Dumitrascu discussed how multi-layered data can be integrated and analyzed with advanced mathematical approaches, and provided future perspectives.

The series of lectures highlighted that the progress of molecular biology and mathematics are stimulating each other to develop the single-cell biology field. We hope the workshop was full of inspiration for all the participants.


Friday, 10 December 2021
Zoom Online Meeting
- Highspeed LAN/WiFi environment advised for stability
- Update the software to the latest version


Researchers and students


Opening Remarks

9:00-9:05 Taro Tsujimura, ASHBi, Kyoto University

Keynote lecture 1 (Chair: Yasuaki Hiraoka, ASHBi)

9:05-10:05 Geoffrey Schiebinger, University of British Columbia
Towards a Mathematical Theory of Development
10:05–10:20 Meet the speaker
10:20–10:30 Break

Session 1: Genome regulation by single-cell analysis (Chair: Taro Tsujimura, ASHBi)

10:30–11:00 Tomoko Nishiyama, Nagoya University
Single-molecule approach for understanding genome architecture
11:00–11:30 Yodai Takei, California Institute of Technology
Single-cell nuclear architecture across cell types by integrated spatial genomics
11:30–12:00 Hiroshi Ochiai, Hiroshima University
Genome-wide kinetic properties of transcriptional bursting revealed by single cell analysis
12:00–12:15 Meet the speakers from Session 1
12:15–13:30 Lunch Break

Session 2: Data science in single-cell analysis (Chair: Toshiaki Yachimura, ASHBi)

13:30–14:00 Chung Chau Hon, RIKEN IMS
An atlas of transcribed cis-regulatory elements in human single-cells for understanding genetic predispositions to diseases
14:00–14:30 Yoshihiro Yamanishi, Kyushu Institute of Technology
Large-scale analysis of drug-induced transcriptome data by machine learning
14:30–15:00 Yusuke Imoto, ASHBi, Kyoto Univeristy
Resolution of the curse of dimensionality in single-cell analysis
15:00–15:15 Meet the speakers from Session 2
15:15–15:30 Break

Session 3: Applications with single-cell analysis (Chair: Takuya Yamamoto, ASHBi)

15:30–16:00 Ryo Yamamoto, ASHBi, Kyoto University
In vivo/in silico single-cell analysis of hematopoietic stem cells
16:00–16:30 Yutaka Suzuki, The University of Tokyo
Application of the single cell and spatial transcriptome analyses for clinical cancer specimens
16:30–16:45 Meet the speakers from Session 3
16:45–17:00 Break

Keynote lecture 2 (Chair: Mitinori Saitou, ASHBi)

17:00-18:00 Bianca Dumitrascu, Cambridge University
Beyond multi-modal analysis: challenges and interpretability for single cell data

Closing Remarks

18:00-18:05 Mitinori Saitou, ASHBi, Kyoto University

Social Interaction

18:05-19:00 held at Spatial Chat


Registered participants only
Registration Form (Google Form)
(Deadline: 8 December 2021 / Number of participants: Limited to 450)

[IMPORTANT] Participants shall not disclose any confidential information to others since unpublished data may appear in the presentations.

We will send the Zoom link approximately one week prior to the Workshop.


Yasuaki Hiraoka, Toshiaki Yachimura,Takuya Yamamoto, Taro Tsujimura, Mitinori Saitou (ASHBi, Kyoto University)


Single-Cell Genome Information Analysis Core (SignAC)

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