Lanying Zhao

Clonal heterogeneity and evolution of MPN revealed by single-cell RNA/DNA sequencing

JAK2 mutations are hallmarks of myeloproliferative neoplasms (MPN), but also found in other myeloid neoplasms, such as myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). While JAK2-mutated MPN cases frequently develop to AML, approximately half of the cases no longer carry JAK2 mutation. These observations suggest a complicated mechanism of mutant JAK2-mediated clonal selection during myeloid leukemogenesis. The aim of the present study was to investigate the effects of JAK2-mutated clones on the clonal evolution of JAK2- wild type clones in leukemic transformation.

Yasuhito Nannya, Magnus Tobiasson, Shinya Sato, Elsa Bernard, Shigeki Ohtake, June Takeda, Maria Creignou, Lanying Zhao, Manabu Kusakabe, Seiji Ogawa et al. (2023). Postazacitidine clone size predicts long-term outcome of patients with myelodysplastic syndromes and related myeloid neoplasms. Blood Advances 7(14), 3624–3636. DOI:10.1182/bloodadvances.2022009564

June Taketa, Kenichi Yoshida, Msahiro M.Nakagawa, Yasuhito Nannya, Akinori Yoda, Ryunosuke Saiki, Yotaro Ochi, Lanying Zhao, Rurika Okuda, Xingxing Qi, Seiji Ogawa, et al. (2022). Amplified EPOR/JAK2 genes define a unique subtype of acute erythroid leukemia. Blood cancer discovery 3(5), 410-427. DOI:10.1158/2643-3230.BCD-21-0192

Yotaro Ochi, Kenichi Yoshida, Lanying Zhao, Ying-Jung Huang, Hideki Makishima, et al. (2021). Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia. Nature Communications 12(1), 2833-2833. DOI:10.1038/s41467-021-23097-w

Masahiro Nakagawa, Ryosaku Inagaki, Yasuhito Nannya, Lanying Zhao, Yotaro Ochi, June Takeda, Xingxing Qi, Akinori Yoda, Ayana Kon, Nobuyuki Kakiuchi, et al. (2021). Early Clonal evolution of myeloid malignancies. Cancer Science 112, 969-969.

Yosaku Watatani, Yasuharu Sato, Hiroaki Miyoshi, Kana Sakamoto, Kenji Nishida, Yuka Gion, Yasunobu Nagata, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Lanying Zhao, Yotaro Ochi, Yasuhide Takeuchi, Hideki Makishima, et al. (2019). Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling. Leukemia 33(12), 2867-2883. DOI:10.1038/s41375-019-0473-1

Yasuhito Nannya, Kenichi Yoshida, Lanying Zhao, June Takeda, Hiroo Ueno, Tetsuichi Yoshizato, Akinori Yoda, Masahiro Nakagawa, Hideki Makishima, Hiroko Tanaka, et al. (2018). Genome-Wide Analysis of Non-Coding Alterations in Pan-Myeloid Cancers Using Whole Genome Sequencing. Blood 132 (Supplement 1), 103. DOI:10.1182/blood-2018-99-116250

Morimoto T, Mineharu Y, Ono K, Nakatochi M, Ichihara S, Kabata R, Takagi Y, Cao Y, Zhao L, Kobayashi H, Harada KH, Takenaka K, Funaki T, Yokota M, Matsubara T, Yamamoto K, Izawa H, Kimura T, Miyamoto S, Koizumi A. (2017). Significant association of RNF213p.R4810K, a moyamoya susceptibility variant, with coronary artery disease. PLoS ONE Apr 17;12(4). DOI:10.1371/journal.pone.0175649

Lanying Zhao, Hirotomo Saitsu, Xiangnan Sun, Kohei Shiota, Makoto Ishibashi. (2010). Sonic hedgehog is involved in formation of the ventral optic cup by limiting Bmp4 expression to the dorsal domain. Mechanisms of Development Jan-Feb;127(1-2), 62-72. DOI:10.1016/j.mod.2009.10.006

Joined

Jul. 1, 2024