ASHBi Fusion Research Program

ASHBi aims to uncover the design principles of human beings and disease states, through a multi-disciplinary science approach. For this purpose, fusion research is highly recommended beyond the boundaries of existing research fields, and we try to generate intellectual inspiration and a collaborative atmosphere among different field researchers. To progressively advance fusion research in ASHBi, we have established the research grant to strengthen fusion research between mathematics and biology, between bioethics and biology, or between biology and biology.

ASHBi Fusion Research Program

Selected Groups

FY2023

Project Title Category Representative Group Members
Building a unifying theoretical and experimental framework of 2½D and 3D cellular and molecular mechanisms for self-organization of limb morphogenesis Math-Bio Rio Tsutsumi Eiraku-G Steffen Plunder、Antoine Diez
High efficiency generation of in vitro embryo models using totipotent cells Bio-Bio Moyra Lawrence T. Yamamoto-G Keun-Tae Kim、Sofiane Hamidi、Jun Okamoto、Yuya Tokuta、Yusuke Imoto
Spatiotemporal reconstruction of gene expression dynamics during early human development Math-Bio Jun Okamoto Hiraoka-G Sofiane Hamidi、Yoshihiro Yamanaka、Toshiaki Yachimura、Yusuke Imoto、Jiwon Bu

FY2022

Project Title Category Representative Group Members
Single-molecule elucidation of higher-order chromatin folding dynamics in individual cells Math-Bio Taro Tsujimura SignAC Killian Meehan、Masahiro Nagano、Bo Hu、Yusuke Imoto、Toshiaki Yachimura、Jacob N. Clark
Unraveling transcriptional regulatory mechanism of transposable elements across species Bio-Bio Masahiro Nagano Saitou-G Xun Chen、Bo Hu、Yusuke Murase、Kazuhiro Takeuchi

FY2021

Project Title Category Representative Group Members
Statistical inference of the causality with polarity among brain regions associated with recovery from spinal cord injury Math-Bio Reona Yamaguchi Isa-G Yusuke Imoto
Reconstruct hematopoiesis using in vivo paired daughter cell assay combined with mathematical integration Math-Bio Tania Afroj R.Yamamoto-G Toshiaki Yachimura, Yusuke Imoto, Shinichiro Oshima
The research use of fresh postmortem tissues: From a regulatory and ethical perspective Ethics-Bio Go Okui Fujita-G Mio Hamatani, Haruka Higashi, Masahiro Nakagawa, Ken Mizuta, Masanori Oikawa, Shinichiro Oshima, Naoya Toriu
Reconstruction and analysis of peri & post-implantation non-human primate development Bio-Bio Sofiane Hamidi Alev-G Shoma Matsumoto, Masanaga Muto, Cantas Alev, Masatsugu Ema
Spatial transcriptome analysis of human axial development in vitro Bio-Bio Yoshihiro Yamanaka Alev-G Kazunori Sunadome, Taro Tsujimura, Kumiko Yoshioka-Kobayashi, Sofiane Hamidi, Cantas Alev, Takuya Yamamoto
Functional dissection of primate striatal structure using viral vectors guided by genome informatics Bio-Bio Harumi Saito Amemori-G Shruti Baghat, Satoko Amemori
Genome-wide dynamics of oscillatory transcriptional regulation during human in vitro somitogenesis Bio-Bio Haruka Higashi Murakawa-G Yoshihiro Yamanaka, Sofiane Hamidi
Deciphering regulatory heterogeneity of human hematopoietic stem and progenitor cells Bio-Bio Shruti Bhagat Murakawa-G Tania Afroj

FY2020

Project Title Category Representative Group Members
Characterization of gene regulatory networks in human and non-human in vitro segmentation clocks Math-Bio Kumiko Yoshioka-Kobayashi Alev-G Yoshihiro Yamanaka, Toshiaki Yachimura, Cantas Alev
Mathematical modelling and experimental modulation of the dynamics of human osteogenesis Math-Bio Yusuke Seto Eiraku-G Sohei Tasaki
Inference of genome-wide DNA demethylation kinetics by dynamic model fitting Research Math-Bio Sohei Tasaki Hiraoka-G Yukihiro Yabuta, Yusuke Murase
Identification of multi-resolution cell differentiation dynamics from scRNA-seq data via mathematical data analysis and interactive visualization system Math-Bio Yusuke Imoto Hiraoka-G Yoji Kojima, Tomonori Nakamura, Hiroaki Natsukawa, Takashi Nicholas Maeda
Topological approaches for integrative 3D epigenomics Math-Bio Taro Tsujimura SignAC Yusuke Imoto, Masahiro Nagano, Killian Meehan, Bo Hu, Jacob N. Clark
Examining Ethics and Governance in Developmental Biology Ethics-Bio Tsutomu Sawai Fujita-G Go Okui, Cantas Alev
Deciphering evolutionary differences of germline transposable element dynamics Bio-Bio Xun Chen Brouque-G Yusuke Murase, Masahiro Nagano, Bo Hu