Support for Long-Read Single-Molecule Epigenome Analysis

Long-read sequencing is a technology that enables the analysis of DNA sequences and base modification states over tens of thousands of bases single DNA molecules. Through this technology, it is possible to determine the true nature of genomic molecules that function over very long distances, such as through interactions between regulatory regions. SignAC has two large-scale long-read sequencing platforms, ONT’s PromethION24 and PacBio’s Sequel IIe, and conducts support and advanced research for single-molecule epigenome analysis as part of the AMED BINDS project.

Specific support includes full-length transcriptome analysis, long-read methylome analysis, and multicontact chromatin conformation analysis. As a research technological advancement, our primary focus is on the development of these single-cell analysis technologies.