Alasaadi, D.N., Alvizi, L., Hartmann, J., Stillman, N., Moghe, P., Hiiragi, T. and Mayor, R. Competence for neural crest induction is controlled by hydrostatic pressure through Yap. Nature Cell Biology 26, 530-541.(2024)LINK
2023
Bondarenko, V., Nikolaev, M., Kromm, D., Belousov, R., Wolny, A., Blotenburg, M., Zeller, P., Rezakhani, S., Hugger, J., Uhlmann, V., Hufnagel, L., Kreshuk, A., Ellenberg, J., van Oudenaarden, A., Erzberger, A., Lutolf, M. P., & Hiiragi, T. (2023). Embryo-uterine interaction coordinates mouse embryogenesis during implantation. The EMBO journal, 42(17), e113280.LINK
Prachiti Moghe, Roman Belousov, Takafumi Ichikawa, Chizuru Iwatani, Tomoyuki Tsukiyama, François Graner, Anna Erzberger, Takashi Hiiragi. Apical-driven cell sorting optimised for tissue geometry ensures robust patterning. bioRxiv (2023)LINK
Fabrèges, D., Murtra, B. C., Moghe, P., Kickuth, A., Ichikawa, T., Iwatani, C., Tsukiyama, T., Daniel, N., Gering, J., Stokkermans, A., Wolny, A., Kreshuk, A., Duranthon, V., Uhlmann, V., Hannezo, E., & Hiiragi, T. Temporal variability and cell mechanics control robustness in mammalian embryogenesis. bioRxiv (2023).LINK
2022
Stokkermans, A., Chakrabarti, A., Subramanian, K., Wang, L., Yin, S., Moghe, P., Steenbergen, P., Mönke, G., Hiiragi, T., Prevedel, R., Mahadevan, L., & Ikmi, A. (2022). Muscular hydraulics drive larva-polyp morphogenesis. Current biology, 32(21), 4707–4718.e8.LINKPress release
Korotkevich, E., & Hiiragi, T. (2022). Major construction entails major demolition. Developmental cell, 57(11), 1311–1313.LINK
Ichikawa, T., Zhang, H. T., Panavaite, L., Erzberger, A., Fabrèges, D., Snajder, R., Wolny, A., Korotkevich, E., Tsuchida-Straeten, N., Hufnagel, L., Kreshuk, A., & Hiiragi, T. (2022). An ex vivo system to study cellular dynamics underlying mouse peri-implantation development. Developmental Cell, 57(3), 373–386.e9.LINKPress release
Kim, E., Sorokin, L., & Hiiragi, T. (2022). ECM-integrin signalling instructs cellular position sensing to pattern the early mouse embryo. Development, 149(1), dev200140.LINK
2021
Yang, Q., Xue, S. L., Chan, C. J., Rempfler, M., Vischi, D., Maurer-Gutierrez, F., Hiiragi, T., Hannezo, E., & Liberali, P. (2021). Cell fate coordinates mechano-osmotic forces in intestinal crypt formation. Nature Cell Biology, 23(7), 733–744.LINK
Roffay, C., Chan, C. J., Guirao, B., Hiiragi, T., & Graner, F. (2021). Inferring cell junction tension and pressure from cell geometry. Development, 148(18), dev192773.LINK
2020
Chan, C. J., & Hiiragi, T. (2020). Integration of luminal pressure and signalling in tissue self-organization. Development, 147(5), dev181297.LINK
2019
Ryan, A. Q., Chan, C. J., Graner, F., & Hiiragi, T. (2019). Lumen Expansion Facilitates Epiblast-Primitive Endoderm Fate Specification during Mouse Blastocyst Formation. Developmental Cell, 51(6), 684–697.e4.LINK
Niwayama, R., Moghe, P., Liu, Y. J., Fabrèges, D., Buchholz, F., Piel, M., & Hiiragi, T. (2019). A Tug-of-War between Cell Shape and Polarity Controls Division Orientation to Ensure Robust Patterning in the Mouse Blastocyst. Developmental Cell, 51(5), 564–574.e6.LINK
Chan, C. J., Costanzo, M., Ruiz-Herrero, T., Mönke, G., Petrie, R. J., Bergert, M., Diz-Muñoz, A., Mahadevan, L., & Hiiragi, T. (2019). Hydraulic control of mammalian embryo size and cell fate. Nature, 571(7763), 112–116.LINK
2018
Zhang, H. T., & Hiiragi, T. (2018). Symmetry Breaking in the Mammalian Embryo. Annual Review of Cell and Developmental Biology, 34, 405–426.LINK
Reichmann, J., Nijmeijer, B., Hossain, M. J., Eguren, M., Schneider, I., Politi, A. Z., Roberti, M. J., Hufnagel, L., Hiiragi, T., & Ellenberg, J. (2018). Dual-spindle formation in zygotes keeps parental genomes apart in early mammalian embryos. Science, 361(6398), 189–193.LINK
Kim, E., Korotkevich, E., & Hiiragi, T. (2018). Coordination of Cell Polarity, Mechanics and Fate in Tissue Self-organization. Trends in Cell Biology, 28(7), 541–550.LINK
2017
Chan, C. J., & Hiiragi, T. (2017). Keeping in Touch to Differentiate. Developmental Cell, 43(2), 113–114.LINK
Chan, C. J., Heisenberg, C. P., & Hiiragi, T. (2017). Coordination of Morphogenesis and Cell-Fate Specification in Development. Current Biology, 27(18), R1024–R1035.LINK
Veldhuis, J. H., Ehsandar, A., Maître, J. L., Hiiragi, T., Cox, S., & Brodland, G. W. (2017). Inferring cellular forces from image stacks. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 372(1720), 20160261.LINK
Korotkevich, E., Niwayama, R., Courtois, A., Friese, S., Berger, N., Buchholz, F., & Hiiragi, T. (2017). The Apical Domain Is Required and Sufficient for the First Lineage Segregation in the Mouse Embryo. Developmental Cell, 40(3), 235–247.e7.LINK
2016
Maître, J. L., Turlier, H., Illukkumbura, R., Eismann, B., Niwayama, R., Nédélec, F., & Hiiragi, T. (2016). Asymmetric division of contractile domains couples cell positioning and fate specification. Nature, 536(7616), 344–348.LINK
de Medeiros, G., Norlin, N., Gunther, S., Albert, M., Panavaite, L., Fiuza, U. M., Peri, F., Hiiragi, T., Krzic, U., & Hufnagel, L. (2015). Confocal multiview light-sheet microscopy. Nature Communications, 6, 8881.LINK
Dietrich, J. E., Panavaite, L., Gunther, S., Wennekamp, S., Groner, A. C., Pigge, A., Salvenmoser, S., Trono, D., Hufnagel, L., & Hiiragi, T. (2015). Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. EMBO reports, 16(8), 1005–1021.LINK
Maître, J. L., Niwayama, R., Turlier, H., Nédélec, F., & Hiiragi, T. (2015). Pulsatile cell-autonomous contractility drives compaction in the mouse embryo. Nature Cell Biology, 17(7), 849–855.LINK
2014
Ohnishi, Y., Huber, W., Tsumura, A., Kang, M., Xenopoulos, P., Kurimoto, K., Oleś, A. K., Araúzo-Bravo, M. J., Saitou, M., Hadjantonakis, A. K., & Hiiragi, T. (2014). Cell-to-cell expression variability followed by signal reinforcement progressively segregates early mouse lineages. Nature Cell Biology, 16(1), 27–37.LINK
2013
Wennekamp, S., Mesecke, S., Nédélec, F., & Hiiragi, T. (2013). A self-organization framework for symmetry breaking in the mammalian embryo. Nature Reviews. Molecular Cell Biology, 14(7), 452–459.LINK
2012
Courtois, A., Schuh, M., Ellenberg, J., & Hiiragi, T. (2012). The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development. The Journal of Cell Biology, 198(3), 357–370.LINK
Lavial, F., Bessonnard, S., Ohnishi, Y., Tsumura, A., Chandrashekran, A., Fenwick, M. A., Tomaz, R. A., Hosokawa, H., Nakayama, T., Chambers, I., Hiiragi, T., Chazaud, C., & Azuara, V. (2012). Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development. Genes & Development, 26(13), 1445–1458.LINK
Groner, A. C., Tschopp, P., Challet, L., Dietrich, J. E., Verp, S., Offner, S., Barde, I., Rodriguez, I., Hiiragi, T., & Trono, D. (2012). The Krüppel-associated box repressor domain can induce reversible heterochromatization of a mouse locus in vivo. The Journal of Biological Chemistry, 287(30), 25361–25369.LINK
2008
Honda, H., Motosugi, N., Nagai, T., Tanemura, M., & Hiiragi, T. (2008). Computer simulation of emerging asymmetry in the mouse blastocyst. Development, 135(8), 1407–1414.LINK
Bauer, T., Motosugi, N., Miura, K., Sabe, H., & Hiiragi, T. (2008). Dynamic rearrangement of surface proteins is essential for cytokinesis. Genesis, 46(3), 152–162.LINK
2007
Dietrich, J. E., & Hiiragi, T. (2007). Stochastic patterning in the mouse pre-implantation embryo. Development, 134(23), 4219–4231.LINK
2006
Hiiragi, T., Alarcon, V. B., Fujimori, T., Louvet-Vallee, S., Maleszewski, M., Marikawa, Y., Maro, B., & Solter, D. (2006). Where do we stand now? Mouse early embryo patterning meeting in Freiburg, Germany (2005). The International Journal of Developmental Biology, 50(7), 581–587.LINK
Hiiragi, T., Louvet-Vallée, S., Solter, D., & Maro, B. (2006). Does prepatterning occur in the mouse egg?. Nature, 442(7099), E3–E4.LINK
Motosugi, N., Dietrich, J. E., Polanski, Z., Solter, D., & Hiiragi, T. (2006). Space asymmetry directs preferential sperm entry in the absence of polarity in the mouse oocyte. PLoS Biology, 4(5), e135.LINK
2005
Motosugi, N., Bauer, T., Polanski, Z., Solter, D., & Hiiragi, T. (2005). Polarity of the mouse embryo is established at blastocyst and is not prepatterned. Genes & Development, 19(9), 1081–1092.LINK
2004
Hiiragi, T., & Solter, D. (2004). First cleavage plane of the mouse egg is not predetermined but defined by the topology of the two apposing pronuclei. Nature, 430(6997), 360–364.LINK