Elucidation of the neural mechanism of anxiety and conflict

ResearchResearch

We will study neuroscience to examine the function of the emotional circuit in non-human primates (NHPs), whose brain structure is homologous to that of humans. The Amemori Group focuses on the NHP’s limbic system. In particular, the group aims to identify the neural basis of the interareal interaction of macaques’ anxiety-related network by combining electrical-stimulation and fMRI methods. The group will perform neurophysiological recordings of spikes and field potentials from microelectrodes chronically-implanted into multiple brain sites. The group also aims to clarify the function of the cerebral cortex, basal ganglia, and dopamine-related circuit in order to elucidate the mechanism of anxiety. The group will also introduce genetic engineering such as chemogenetics to clarify the mechanism of the anxiety-related circuit.

Research

Pubilications Publications

  • Cingulate microstimulation induces negative decision-making via reduced top-down influence on primate fronto-cingulo-striatal networkView Publications
  • Spatiotemporal expression patterns of anxiety disorder-associated genes Karunakaran, K.B., Amemori, Ki. Transl Psychiatry 13, 385 (2023).査読ありView Publications

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