ASHBi aims to uncover the design principles of human beings and disease states, through a multi-disciplinary science approach. For this purpose, fusion research is highly recommended beyond the boundaries of existing research fields, and we try to generate intellectual inspiration and a collaborative atmosphere among different field researchers. To progressively advance fusion research in ASHBi, we have established the research grant to strengthen fusion research between mathematics and biology, between bioethics and biology, or between biology and biology.
Selected Groups
FY2023
| Project Title | Category | Representative | Group | Members |
|---|---|---|---|---|
| Building a unifying theoretical and experimental framework of 2½D and 3D cellular and molecular mechanisms for self-organization of limb morphogenesis | Math-Bio | Rio Tsutsumi | Eiraku-G | Steffen Plunder Antoine Diez |
| High efficiency generation of in vitro embryo models using totipotent cells | Bio-Bio | Moyra Lawrence | T. Yamamoto-G | Keun-Tae Kim Sofiane Hamidi Jun Okamoto Yuya Tokuta Yusuke Imoto |
| Spatiotemporal reconstruction of gene expression dynamics during early human development | Math-Bio | Jun Okamoto | Hiraoka-G | Sofiane Hamidi Yoshihiro Yamanaka Toshiaki Yachimura Yusuke Imoto Jiwon Bu |
FY2022
| Project Title | Category | Representative | Group | Members |
|---|---|---|---|---|
| Single-molecule elucidation of higher-order chromatin folding dynamics in individual cells | Math-Bio | Taro Tsujimura | SignAC | Killian Meehan Masahiro Nagano Bo Hu Yusuke Imoto Toshiaki Yachimura Jacob N. Clark |
| Unraveling transcriptional regulatory mechanism of transposable elements across species | Bio-Bio | Masahiro Nagano | Saitou-G | Xun Chen Bo Hu Yusuke Murase Kazuhiro Takeuchi |
FY2021
| Project Title | Category | Representative | Group | Members |
|---|---|---|---|---|
| Statistical inference of the causality with polarity among brain regions associated with recovery from spinal cord injury | Math-Bio | Reona Yamaguchi | Isa-G | Yusuke Imoto |
| Reconstruct hematopoiesis using in vivo paired daughter cell assay combined with mathematical integration | Math-Bio | Tania Afroj | R.Yamamoto-G | Toshiaki Yachimura Yusuke Imoto Shinichiro Oshima |
| The research use of fresh postmortem tissues: From a regulatory and ethical perspective | Ethics-Bio | Go Okui | Fujita-G | Mio Hamatani Haruka Higash Masahiro Nakagawa Ken Mizuta Masanori Oikawa Shinichiro Oshima Naoya Toriu |
| Reconstruction and analysis of peri & post-implantation non-human primate development | Bio-Bio | Sofiane Hamidi | Alev-G | Shoma Matsumoto Masanaga Muto Cantas Alev Masatsugu Ema |
| Spatial transcriptome analysis of human axial development in vitro | Bio-Bio | Yoshihiro Yamanaka | Alev-G | Kazunori Sunadome Taro Tsujimura Kumiko Yoshioka-Kobayashi Sofiane Hamidi Cantas Alev Takuya Yamamoto |
| Functional dissection of primate striatal structure using viral vectors guided by genome informatics | Bio-Bio | Harumi Saito | Amemori-G | Shruti Baghat Satoko Amemori |
| Genome-wide dynamics of oscillatory transcriptional regulation during human in vitro somitogenesis | Bio-Bio | Haruka Higashi | Murakawa-G | Yoshihiro Yamanaka Sofiane Hamidi |
| Deciphering regulatory heterogeneity of human hematopoietic stem and progenitor cells | Bio-Bio | Shruti Bhagat | Murakawa-G | Tania Afroj |
FY2020
| Project Title | Category | Representative | Group | Members |
|---|---|---|---|---|
| Characterization of gene regulatory networks in human and non-human in vitro segmentation clocks | Math-Bio | Kumiko Yoshioka-Kobayashi | Alev-G | Yoshihiro Yamanaka Toshiaki Yachimura Cantas Alev |
| Mathematical modelling and experimental modulation of the dynamics of human osteogenesis | Math-Bio | Yusuke Seto | Eiraku-G | Sohei Tasaki |
| Inference of genome-wide DNA demethylation kinetics by dynamic model fitting Research | Math-Bio | Sohei Tasaki | Hiraoka-G | Yukihiro Yabuta Yusuke Murase |
| Identification of multi-resolution cell differentiation dynamics from scRNA-seq data via mathematical data analysis and interactive visualization system | Math-Bio | Yusuke Imoto | Hiraoka-G | Yoji Kojima Tomonori Nakamura Hiroaki Natsukawa Takashi Nicholas Maeda |
| Topological approaches for integrative 3D epigenomics | Math-Bio | Taro Tsujimura | SignAC | Yusuke Imoto Masahiro Nagano Killian Meehan Bo Hu Jacob N. Clark |
| Examining Ethics and Governance in Developmental Biology | Ethics-Bio | Tsutomu Sawai | Fujita-G | Go Okui Cantas Alev |
| Deciphering evolutionary differences of germline transposable element dynamics | Bio-Bio | Xun Chen | Brouque-G | Yusuke Murase Masahiro Nagano Bo Hu |