July 5, 2024

Unravelling CD4 T cell diversity by active enhancer mapping and their role in immune disease

According to Japanese folklore, 7th of July is the only day of the year when the two stars, Altair and Vega – Hikoboshi and Orihime, can meet at the Milky way. Similarly, in our genome, enhancers “meet” promoters at the necessary times to regulate the expression of genes…

Credit:Kanon Tanaka

A research team led by Dr. Yasuhiro Murakawa has published the research article in Science.

Link to news release

Paper information

Oguchi, A., Suzuki, A., Komatsu, S., Yoshitomi, H., Bhagat, S., Son, R., Bonnal, R. J. Pierre, Kojima, S., Koido, M., Takeuchi, K., Myouzen, K., Inoue, G., Hirai, T., Sano, H., Takegami, Y., Kanemaru, A., Yamaguchi, I., Ishikawa, Y., Tanaka, N., … Murakawa, Y. (2024). An Atlas of Transcribed Enhancers across Helper T Cell Diversity for Decoding Human Diseases. Science. 10.1126/science.add8394