Lanying Zhao
| Position | Assistant Professor |
|---|---|
| Group name | Ogawa Group |
| Research Field | Pathology and Tumor Biology |
| ORCID | https://orcid.org/0000-0002-3959-0699 |
| Joined | Jul. 1, 2024 |
Research Overview
Clonal heterogeneity and evolution of MPN revealed by single-cell RNA/DNA sequencing
JAK2 mutations are hallmarks of myeloproliferative neoplasms (MPN), but also found in other myeloid neoplasms, such as myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). While JAK2-mutated MPN cases frequently develop to AML, approximately half of the cases no longer carry JAK2 mutation. These observations suggest a complicated mechanism of mutant JAK2-mediated clonal selection during myeloid leukemogenesis. The aim of the present study was to investigate the effects of JAK2-mutated clones on the clonal evolution of JAK2- wild type clones in leukemic transformation.
Biography
Lanying Zhao obtained her PhD from Kyoto University (2010) and moved to Kyoto University Graduate School of Medicine (2010-2018) as a postdoc. She was appointed Program-Specific Assistant Professor in 2018 in Kyoto University Institute for the Advanced Study of Human Biology. From 2022-2024, She was a part-time researcher at in Kyoto University Institute for the Advanced Study of Human Biology. In July 2024 she was appointed Program-Specific Assistant Professor in 2018 in Kyoto University Institute for the Advanced Study of Human Biology, to the present.
Publications
Yasuhito Nannya, Magnus Tobiasson, Shinya Sato, Elsa Bernard, Shigeki Ohtake, June Takeda, Maria Creignou, Lanying Zhao, Manabu Kusakabe, Seiji Ogawa et al. (2023). Postazacitidine clone size predicts long-term outcome of patients with myelodysplastic syndromes and related myeloid neoplasms. Blood Advances 7(14), 3624–3636. DOI:10.1182/bloodadvances.2022009564
June Taketa, Kenichi Yoshida, Msahiro M.Nakagawa, Yasuhito Nannya, Akinori Yoda, Ryunosuke Saiki, Yotaro Ochi, Lanying Zhao, Rurika Okuda, Xingxing Qi, Seiji Ogawa, et al. (2022). Amplified EPOR/JAK2 genes define a unique subtype of acute erythroid leukemia. Blood cancer discovery 3(5), 410-427. DOI:10.1158/2643-3230.BCD-21-0192
Yotaro Ochi, Kenichi Yoshida, Lanying Zhao, Ying-Jung Huang, Hideki Makishima, et al. (2021). Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia. Nature Communications 12(1), 2833-2833. DOI:10.1038/s41467-021-23097-w
Masahiro Nakagawa, Ryosaku Inagaki, Yasuhito Nannya, Lanying Zhao, Yotaro Ochi, June Takeda, Xingxing Qi, Akinori Yoda, Ayana Kon, Nobuyuki Kakiuchi, et al. (2021). Early Clonal evolution of myeloid malignancies. Cancer Science 112, 969-969.
Yosaku Watatani, Yasuharu Sato, Hiroaki Miyoshi, Kana Sakamoto, Kenji Nishida, Yuka Gion, Yasunobu Nagata, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Lanying Zhao, Yotaro Ochi, Yasuhide Takeuchi, Hideki Makishima, et al. (2019). Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling. Leukemia 33(12), 2867-2883. DOI:10.1038/s41375-019-0473-1