Kazunori Sunadome
| Position | Assistant Professor |
|---|---|
| Group name | T. Yamamoto Group |
| Research Field | Cell Biology |
| Joined | Feb. 1, 2020 |
Research Overview
I am interested in when, where, and how cell fate is determined, as well as in the molecular diversity that governs these processes. RNA is not merely a mediator between the genome and proteins; it regulates cell fate and cellular states through complex mechanisms, including transcriptional control, splicing, and intracellular localization.
To explore this complexity, I have developed a 3D spatial transcriptomics technology (see movie) that enables visualization of RNA distribution and cell fate dynamics within intact tissues. In addition, by integrating this method with the CRISPR system, I am developing an in situ functional screening platform and a high-content lineage tracing system.
Through these efforts, I aim to elucidate how RNA diversity contributes to tissue formation and homeostasis, and to uncover new principles underlying the organization of living systems.
Biography
Kazunori Sunadome obtained his PhD from Kyoto Univeristy (2011), and undertook postdoctoral training in King’s College London (2013-2014) and Karolinska Institute (2015-2020). He joined Dr Takuya Yamamoto’s group from February 2020.
Publications
Directionality of developing skeletal muscles is set by mechanical forces. Nat Commun . 14: 3060 (2023). Sunadome K, Erickson AG, Kah D, Fabry B, Adori C, Kameneva P, Faure L, Kanatani S, Kaucka M, Ellström ID, Tesarova M, Zikmund T, Kaiser J, Edwards S, Maki K, Adachi T, Yamamoto T, Fried K, and Adameyko I
Reconstituting human somitogenesis in vitro. Nature. 614: 509-520 (2023) Yamanaka Y, Hamidi S, Yoshioka-Kobayashi K, Munira S, Sunadome K, Zhang Y, Kurokawa Y, Ericsson R, Mieda A, Thompson JL, Kerwin J, Lisgo S, Yamamoto T, Moris N, Martinez-Arias A, Tsujimura T, and Alev C
Theory of branching morphogenesis by local interactions and global guidance. Nat Commun. 12: 6830 (2021) Uçar MC, Kamenev D, Sunadome K, Fachet D, Lallemend F, Adameyko I, Hadjab S, and Hannezo E
Antagonism between the master regulators of differentiation ensures the discreteness and robustness of cell fates. Mol Cell. 54: 526-35 (2014) Sunadome K, Suzuki T, Usui M, Ashida Y, and Nishida E
ERK5 regulates muscle cell fusion through Klf transcription factors. Dev Cell. 20: 192-205 (2011) Sunadome K, Yamamoto T, Ebisuya M, Kondoh K, Sehara-Fujisawa A, and Nishida E