Kyoto University Institute for the
Advanced Study of Human Biology


鳥生 直哉

鳥生 直哉


Research Field



1. ヒトiPS細胞由来オルガノイドでの腎臓病モデルの確立

2. DoHAD学説の解明
低出生体重児は成人してから慢性腎不全などの生活習慣病を発症しやすいことがわかっています。このように生活習慣病の発症が胎内環境に影響されるという学説をDoHAD (Developmental Origins of Health and Disease)学説といいます。我々はPIC(Photo Isolation Chemistry)-RNAseqという単一細胞レベルで遺伝子発現を検出できる技術を使い、DoHAD学説の解明を目指したいと考えています。




1. Sato Y, Oguchi A, Fukushima Y, Masuda K, Toriu N, Taniguchi K, Yoshikawa T, Cui X, Kondo M, Hosoi T, Komidori S, Shimizu Y, Fujita H, Jiang L, Kong Y, Yamanashi T, Seita J, Yamamoto T, Toyokuni S, Hamazaki Y, Hattori M, Yoshikai Y, Boor P, Floege J, Kawamoto H, Murakawa Y, Minato N, Yanagita M: CD153-CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury. J Clin Invest 2021.

2. Toriu N, Sumida K, Mizuno H, Hasegawa E, Suwabe T, Kawada M, et al. Long-term outcome of biopsy-proven cholesterol crystal embolism. Clinical and experimental nephrology. 2019;23(10):1181-7.

3. Toriu N, Sumida K, Oguro M, Oshima Y, Mizuno H, Hasegawa E, et al. Increase of 1,25 dihydroxyvitamin D in sarcoidosis patients with renal dysfunction. Clinical and experimental nephrology. 2019;23(10):1202-10.

4. Toriu N, Sawa N, Hiramatsu R, Mizuno H, Ikuma D, Sekine A, et al. Regression of renal amyloid deposits by VAD therapy plus autologous stem cell transplantation in a patient with primary AL amyloidosis. CEN Case Rep. 2020;9(1):6-10.

5. Toriu N, Ueno T, Mizuno H, Sekine A, Hayami N, Hiramatsu R, et al. Brown tumor diagnosed three years after parathyroidectomy in a patient with nail-patella syndrome: A case report. Bone Rep. 2019;10:100187.

6. Toriu N, Sekine A, Mizuno H, Hasegawa E, Yamanouchi M, Hiramatsu R, et al. Renal-Limited Thrombotic Microangiopathy due to Bevacizumab Therapy for Metastatic Colorectal Cancer: A Case Report. Case reports in oncology. 2019;12(2):391-400.

7. Toriu N, Yamanouchi M, Hiramatsu R, Hayami N, Hoshino J, Sekine A, et al. Preservation of renal function by intensive glycemic control. Endocrinol Diabetes Metab Case Rep. 2018;2018.

8. Toriu N, Yamanouchi M, Hiramatsu R, Hayami N, Hoshino J, Sekine A, et al. Tocilizumab prevents renal function of a patient with diabetic kidney disease: case report. Modern Rheumatology Case Reports. 2018;3(1):53-6.

9. Toriu N, Mizuno H, Sawa N, Sumida K, Suwabe T, Hayami N, et al. Everolimus Reduces the Size of Tuberous Sclerosis Complex-Related Huge Renal Angiomyolipomas Exceeding 20 cm in the Longest Diameter. Case reports in oncology. 2018;11(2):258-67.

10. Toriu N, Hoshino J, Kobori S, Watanabe S, Oguro M, Oshima Y, et al. Transcatheter Arterial Embolization Therapy for Huge Renal Cysts: Two Case Reports. Case Rep Nephrol Dial. 2018;8(1):82-9.


Excellence in research award (ASHBi Retreat 2022)



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