Nicholas Thomas Younger
| Position | 研究員 |
|---|---|
| 研究グループ | Alevグループ |
| Research Field | Developmental and Synthetic Biology |
| ORCID | https://orcid.org/0000-0001-7601-9283 |
略歴
Nicholas obtained his BSc in Human Embryology from the University of Aberdeen (UK) and PhD in Genetics and Molecular Medicine from the University of Edinburgh (PhD). He has since carried out postdoctoral research in bioinformatics for the Human Cell Atlas and molecular genetics research studying enhancer usage during craniofacial development. He currently works between Edinburgh and Kyoto.
論文
In vivo modeling of patient genetic heterogeneity identifies new ways to target cholangiocarcinoma. Cancer Research. 2022 Apr 15;82(8):1548-1559 NT Younger et al. DOI: 10.1158/0008-5472.CAN-21-2556
Loss of colonic fidelity enables multilineage plasticity and metastasis. Nature. 644, 547–556 (2025) Patrizia Cammareri, Michela Raponi, Yourae Hong, Caroline V. Billard, Nat Peckett, Yujia Zhu, Fausto D. Velez-Bravo, Nicholas T. Younger. et al. . https://doi.org/10.1038/s41586-025-09125-5
Multimodal decoding of human liver regeneration. Nature. 2024 Jun;630(8015):158-165 Matchett KP, Wilson-Kanamori JR, Portman JR, Kapourani CA, Fercoq F, May S, Zajdel E, Beltran M, Sutherland EF, Mackey JBG, Brice M, Wilson GC, Wallace SJ, Kitto L, Younger NT et al. DOI: 10.1038/s41586-024-07376-2
Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage. Science Translational Medicine. 2022 Dec 7;14(674) Ferreira-Gonzalez S, Man TY, Esser H, Aird R, Kilpatrick AM, Rodrigo-Torres D, Younger N, et al. DOI: 10.1126/scitranslmed.abj4375
Van Gogh-like 2 is essential for the architectural patterning of the mammalian biliary tree. J Hepatol. 2024 Jul;81(1):108-119. Raab M, Christodoulou E, Krishnankutty R, Gradinaru A, Walker AD, Olaizola P, Younger NT, et al. DOI: https://doi.org/10.1016/j.jhep.2024.02.030
RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer. Nature Communications. 2022 May 19;13(1):2791 Hall AE, Pohl SÖ, Cammareri P, Aitken S, Younger NT, et al. DOI: 10.1038/s41467-022-30489-z
Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors. Nature Communications 11, 445 (2020). D.H. Wilson, E.J. Jarman, R.P. Mellin, M.L. Wilson, S.H. Waddell, P. Tsokkou, N.T. Younger et al. DOI: 10.1038/s41467-020-14283-3