Decoding and Engineering Human Immune System with Advanced Technologies

We are delighted to host the mini-symposium on “Decoding and Engineering Human Immune System with Advanced Technologies,” taking place on December 15, 2025.

At this symposium, leading researchers in human immunology and developers of cutting-edge technologies—such as artificial intelligence, single-cell and spatial transcriptomics, and proteomics—will come together. By harnessing these emerging technologies, we aim to deepen discussions that uncover the fundamental mechanisms of the human immune system, which is full of unknowns.

We warmly invite anyone interested to join us.

Outline

Eligibility

All Academic Researchers and students

Registration

Advance online registration is required for all participants.

Speakers

• Daisuke Akiyama | Kyoto University, JP
• Yasushi Ishihama | Kyoto University, JP
• Shinichiro Kato | Kyoto University, JP
• Antonio Lanzavecchia | Istituto Nazionale di Genetica Molecolare (INGM), IT
• Caleb Lareau | Memorial Sloan Kettering Cancer Center, US
• Qirong Lin | Karolinska Institutet, SE
• Luciano Martelotto | BD Biosciences, US
• Federica Sallusto | ETH ZURICH, CH
• Beatrice Scapolo | Technical University of Denmark, DK
• Yuki Sugiura | Kyoto University, JP
• Yuya Tokuta | Kyoto University, JP
• Hiroyuki Yoshitomi | Kyoto University, JP

Timetable

10:00–	Reception
10:25–10:30	Opening Remarks

Session 1 (chair: Yasuhiro Murakawa)

10:30–10:55	Hiroyuki Yoshitomi | Kyoto Univeristy, JP Peripheral helper T cells go beyond B cell help
10:55–11:20	Yuki Sugiura | Kyoto University, JP Advancing Spatial Metabolomics: High-Resolution IMS for Multi-omic Integration of Tissue Microenvironments
11:20–11:40	Yuya Tokuta | Kyoto University, JP Geometric inference of cross-species transcriptome correspondence using Gromov-Wasserstein optimal transport
11:40–12:05	Caleb Lareau | Memorial Sloan Kettering Cancer Center, US Sequence and structural determinants of efficacious de novo chimeric antigen receptors
12:05–13:30	Break

Session 2 (chair: Hideki Ueno)

13:30–13:50	Daisuke Akiyama | Kyoto University, JP Controlling RNase Activity Is Key to Improving Gene Detection Sensitivity in Granulocyte Single-Cell RNA-seq
13:50–14:10	Qirong Lin | Karolinska Institutet, SK Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics in human tissue
14:10–14:30	Luciano Martelotto | BD Biosciences, US Next Generation of Single-Cell Multiomics from BD
14:30–14:55	Yasushi Ishihama | Kyoto University, JP High throughput proteomics and beyond
14:55–15:25	Break

Session 3 (chair: Hideki Ueno)

15:25–15:45	Shinichiro Kato | Kyoto University, JP Targeting epigenetic and metabolic vulnerabilities of cancer cells to overcome immunotherapy resistance
15:45–16:05	Beatrice Scapolo | Technical University of Denmark, DK De novo design of pMHC-specific minibinders for targeted cancer immunotherapy
16:05–16:30	Federica Sallusto | ETH Zurich, CH Clonal analysis of human regulatory T cells targeting microbes and tissue antigens
16:30–16:55	Antonio Lanzavecchia | INGM, IT The Power of Clonal selection: memory, specificity, and crossreactivity
16:55–17:00	Closing Remarks

Access

Nitori Hall, Center for Cancer Immunotherapy and Immunobiology (CCII), Kyoto University​
Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan (Google Map)​

Host

Yasuhiro Murakawa | WPI-ASHBi, Kyoto University, JP

Hideki Ueno | WPI-ASHBi, Kyoto University, JP

Contact

Institute for the Advanced Study of Human Biology (WPI-ASHBi)
ashbi-event[at]mail2.adm.kyoto-u.ac.jp
Please change [at] to @.