Aging leads to numerous changers that affect nearly every component of the immune system. Collectively called “immunosenescence”, that manifest themselves in increased morbidity and mortality of older organisms due to infectious or autoimmune disease. While understanding of immunosenescence has progressed steadily over the past several decades, its underlying mechanisms are still not fully understood.
Various structural and functional dysfunctions appear in aged kidney. For instance, fibrotic changes that are characterized by increased thickness and deposition of collagen bundles in tissues and the proliferation and activation of myofibroblasts, which progresses to a manifest disorganization of kidney architecture and formation of tertiary lymphoid tissues (TLTs). However, the mechanism behind this pathology remains under-investigated, the consequent changes urgently require experimental elucidation and a considerable need for therapeutic propose. Previous animal studies have confirmed that TLTs were found to form in aged injured kidneys that led to sustained inflammation, which delays kidney regeneration, and TLT formation was also confirmed in human kidneys with the components closely similar to those in rodent models. Therefore, I aim to utilize an exploratory based approach, which combines data-based analysis and wet laboratory experiments to investigate the major pathway and molecules involved during the formation of TLTs. The goal of my research is to elucidate the mechanistic relationship between kidney aging and injury with rodents and human models, evaluate the molecular feature during the formation of TLTs and seek for any possibility of translation into therapeutic use.
Xiaotong Cui obtained his PhD from Kyoto University (2018). He was appointed Program-Specific Researcher (Postdoctoral Fellow) in 2020 in ASHBi of Kyoto University.
Nakatsuka, Y., Vandenbon, A., Mino, T., Yoshinaga, M., Uehata, T., Cui, X., Sato, Ayuko., Tsujimura, T., Suzuki, Y., Sato, Atsuyasu., Handa, T., Chin, K., Sawa, T., Hirai, T., Takeuchi, O. (2018). Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia. Mucosal Immunology. 11, 1203-1218(2018).
Cui, X., Mino, T., Yoshinaga, M., Nakatsuka, Y., Hia, F., Yamasoba, D., Tsujimura, T., Tomonaga, K., Suzuki, Y., Uehata, T., Takeuchi, O. (2017). Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis. Journal of Immunology. 199(12):4066-4077.