Troyee Das

Research Overview

Deciphering the genetic and epigenetic landscapes of the human genome is crucial for understanding the molecular basis of human biology, evolution, and disease. In my project, I will utilize multi-omics data, including RNA-seq, scRNA-seq, ChIP-seq, and ATAC-seq, derived from diverse cell types and species, to identify human-specific genetic and epigenetic features in the genome. Additionally, I will integrate these diverse data types and develop advanced bioinformatics tools to uncover novel insights into the genome within the context of human evolution and disease.

Biography

Troyee completed her Masters in Microbiology from University of Calcutta (2016) and PhD in the field of Computational and Molecular Biology from Bose Institute UAC (September 2024). She joined ASHBi, Kyoto University as a Program-Specific Researcher in December 2024.

Publications

Debsharma S, Pramanik S, Bindu S, Mazumder S, Das T, Pal U, Saha D, De R, Nag S, Banerjee C, Maiti N C, Ghosh Z, Bandyopadhyay U: NSAID targets SIRT3 to trigger mitochondrial dysfunction and gastric cancer cell death. iScience,2024

Ghosh B #, Das T #, Das G #, Chowdhury N #, Bagchi A, Ghosh Z: Mapping Drug-gene Interactions to Identify Potential Drug Candidates Targeting Envelope Protein in SARS-CoV-2 Infection. Current Bioinformatics 2023, 18(9):760-773.

Debsharma S, Pramanik S, Bindu S, Mazumder S, Das T, Saha D, De R, Nag S, Banerjee C, Siddiqui AA et al: Honokiol, an inducer of sirtuin-3, protects against non-steroidal anti-inflammatory drug-induced gastric mucosal mitochondrial pathology, apoptosis and inflammatory tissue injury. Br J Pharmacol 2023, 180(18):2317-2340.

Das G, Das T, Parida S, Ghosh Z. LncRTPred: Predicting RNA–RNA mode of interaction mediated by lncRNA. IUBMB Life. 2024; 76(1): 53–68.

Sarkar A #, Das T #, Das G #, Ghosh Z: MicroRNA mediated gene regulatory circuits leads to machine learning based preliminary detection of acute myeloid leukemia. Computational Biology and Chemistry 2023, 104:107859.

Acharya U, Das T, Ghosh Z, Ghosh A: Defense Surveillance System at the Interface: Response of Rice Towards Rhizoctonia solani During Sheath Blight Infection. Molecular Plant-Microbe Interactions® 2022, 35(12):1081-1095.

Debnath S, Sarkar A, Mukherjee DD, Ray S, Mahata B, Mahata T, Parida PK, Das T, Mukhopadhyay R, Ghosh Z et al: Eriodictyol mediated selective targeting of the TNFR1/FADD/TRADD axis in cancer cells induce apoptosis and inhibit tumor progression and metastasis. Translational Oncology 2022, 21:101433.

Ganguly P, Roy D, Das T, Kundu A, Cartieaux F, Ghosh Z, DasGupta M: The Natural Antisense Transcript DONE40 Derived from the lncRNA ENOD40 Locus Interacts with SET Domain Protein ASHR3 During Inception of Symbiosis in Arachis hypogaea. Molecular Plant-Microbe Interactions® 2021, 34(9):1057-1070.

Das G #, Das T #, Chowdhury N #, Chatterjee D #, Bagchi A, Ghosh Z: Repurposed drugs and nutraceuticals targeting envelope protein: A possible therapeutic strategy against COVID-19. Genomics 2021, 113(1, Part 2):1129-1140.

Das T, Deb A, Parida S, Mondal S, Khatua S, Ghosh Z: LncRBase V.2: an updated resource for multispecies lncRNAs and ClinicLSNP hosting genetic variants in lncRNAs for cancer patients. RNA biology 2021, 18(8):1136-1151.