Lanying Zhao

Lanying Zhao

Researcher (Ogawa-G)

Position
Assistant Professor
Research Field
Pathology and Tumor Biology

Research Overview

Clonal heterogeneity and evolution of MPN revealed by single-cell RNA/DNA sequencing

JAK2 mutations are hallmarks of myeloproliferative neoplasms (MPN), but also found in other myeloid neoplasms, such as myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). While JAK2-mutated MPN cases frequently develop to AML, approximately half of the cases no longer carry JAK2 mutation. These observations suggest a complicated mechanism of mutant JAK2-mediated clonal selection during myeloid leukemogenesis. The aim of the present study was to investigate the effects of JAK2-mutated clones on the clonal evolution of JAK2- wild type clones in leukemic transformation.

Biography

Lanying Zhao obtained her PhD from Kyoto University (2010) and moved to Kyoto University Graduate School of Medicine (2010-2018) as a postdoc. She was appointed Program-Specific Assistant Professor in 2018 in Kyoto University Institute for the Advanced Study of Human Biology.

Publications

Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling. Watatani Y, Sato Y, Miyoshi H, Sakamoto K, Nishida K, Gion Y, Nagata Y, Shiraishi Y, Chiba K, Tanaka H, Zhao L, Ochi Y, Takeuchi Y, Takeda J, Ueno H, Kogure Y, Shiozawa Y, Kakiuchi N, Yoshizato T, Nakagawa MM, Nanya Y, Yoshida K, Makishima H, Sanada M, Sakata-Yanagimoto M, Chiba S, Matsuoka R, Noguchi M, Hiramoto N, Ishikawa T, Kitagawa J, Nakamura N, Tsurumi H, Miyazaki T, Kito Y, Miyano S, Shimoda K, Takeuchi K, Ohshima K, Yoshino T, Ogawa S, Kataoka K. Leukemia. 2019 Dec;33(12):2867-2883. doi: 10.1038/s41375-019-0473-1. Epub 2019 May 15

Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease. Morimoto T, Mineharu Y, Ono K, Nakatochi M, Ichihara S, Kabata R, Takagi Y, Cao Y, Zhao L, Kobayashi H, Harada KH, Takenaka K, Funaki T, Yokota M, Matsubara T, Yamamoto K, Izawa H, Kimura T, Miyamoto S, Koizumi A. PLoS One. 2017 Apr 17;12(4).

Sonic hedgehog is involved in formation of the ventral optic cup by limiting Bmp4 expression to the dorsal domain. Zhao L, Saitsu H, Sun X, Shiota K, Ishibashi M.Mech Dev. 2010 Jan-Feb;127(1-2):62-72.

Research Group

Ogawa Group
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